HS-173
货号：
19156-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19156-1mg |
| 描述 | HS-173 is an imidazopyridine analog that acts as a PI3Kα inhibitor with an IC50 value of 0.8 nM.1 It demonstrates antiproliferative activity in T47D, SK-BR-3, and MCF-7 cells with IC50 values of 0.6, 1.5, and 7.8 μM, respectively.1 HS-173 is reported to induce apoptosis by arresting the cell cycle at the G2/M phase and by activating caspases.2,3 It has also been shown to block VEGF-induced angiogenesis both in vitroandin vivo.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, O.,Jeong, Y.,Lee, H., et al. Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis. Journal of Medicinal Chemistry 54(7), 2455-2466 (2011).
2.Lee, H.,Jung, K.H.,Jeong, Y., et al. HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. Cancer Letters 328(1), 152-159 (2013).
3.Son, M.K.,Ryu, Y.L.,Jung, K.H., et al. HS-173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosis. Sci.Rep. 3:3470, (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 422.5 |
| 分子式 | C21H18N4O4S |
| CAS号 | 1276110-06-5 |
| 稳定性 | ≥ 2 years |
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