6-thio-2′-Deoxyguanosine
货号：
19154-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19154-1mg |
| 描述 | 6-thio-2′-Deoxyguanosine (6-thio-dG) is a nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase.1,2 This induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.1 This process occurs in cells expressing telomerase but not in telomerase-negative cells.1 DNA containing 6-thio-dG inhibits the function of RNase H, preventing the cleavage of DNA-RNA heteroduplexes.3 In mouse xenograft studies using A549 lung cancer cells, 6-thio-dG causes a decrease in tumor growth rate associated with telomere dysfunction.1 |
| 别名 | 6-thio-dG;NSC 71261;β-Thioguanine deoxyriboside; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mender, I.,Gryaznov, S.,Dikmen, Z.G., et al. Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2-deoxyguanosine. Cancer Discov. 5(1), 82-95 (2015).
2.Tendian, S.W., and Parker, W.B. Interaction of deoxyguanosine nucleotide analogs with human telomerase. Molecular Pharmaceutics 57, 695-699 (2000).
3.Krynetskaia, N.F.,Krynetski, E.Y., and Evans, W.E. Human RNase H-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6-deoxythioguanosine incorporation into DNA. Molecular Pharmaceutics 56, 841-848 (1999).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 283.3 |
| 分子式 | C10H13N5O3S |
| CAS号 | 789-61-7 |
| 稳定性 | ≥ 2 years |
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