URMC-099
货号：
19147-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19147-1mg |
| 描述 | URMC-099 is an orally bioavailable, brain-penetrant inhibitor of mixed-lineage kinases (MLKs) with IC50 values of 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively.1 It also inhibits LRRK2 activity with an IC50 value of 11 nM.1In vitro, URMC-099 has been shown to reduce inflammatory cytokine production by HIV-1 Tat-exposed microglia and to prevent destruction and phagocytosis of cultured neuronal axons by these cells.2 In rodent models of HIV-associated neurocognitive disorders, URMC-099 demonstrates anti-inflammatory and neuroprotective effects.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Quadro, L.,Blaner, W.S.,Salchow, D.J., et al. Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO Journal 18(17), 4633-4644 (1999).
2.Marker, D.F.,Tremblay, M.É.,Puccini, J.M., et al. The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders. Journal of Neuroscience 33(24), 9998-10010 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 421.5 |
| 分子式 | C27H27N5 |
| CAS号 | 1229582-33-5 |
| 稳定性 | ≥ 2 years |
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