XEN445
货号：
19144-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19144-1mg |
| 描述 | Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as a substrate. XEN445 is an endothelial lipase inhibitor (IC50 = 237 nM) that demonstrates selectivity for endothelial lipase compared to lipoprotein and hepatic lipases (IC50s = 20 and 9.5 µM, respectivley).1 An oral dose of 30 mg/kg XEN445 is reported to increase HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sun, S.,Dean, R.,Jia, Q., et al. Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorganic & Medicinal Chemistry 21(24), 7724-7734 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 366.3 |
| 分子式 | C18H17F3N2O3 |
| CAS号 | 1515856-92-4 |
| 稳定性 | ≥ 2 years |
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