SB 239063
货号：
19142-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 19142-500ug |
| 描述 | SB 239063 is a selective p38 MAPK inhibitor (IC50 = 44 nM for recombinant purified p38α).1 It displays greater than 220-fold selectivity for p38 MAPK over ERK, JNK1, and other kinases.1 SB 239063 has been shown to reduce inflammatory cytokine production in lipopolysaccharide-stimulated human peripheral blood monocytes (IC50s = 0.12 and 0.35 µM, respectively for IL-1 and TNF-α) and is neuroprotective following oral administration in a rat model of cerebral focal ischemia.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Underwood, D.C.,Osborn, R.R.,Kotzer, C.J., et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. Journal of Pharmacology and Experimental Therapeutics 293(1), 281-288 (2000).
2.Barone, F.C.,Irving, E.A.,Ray, A.M., et al. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. Journal of Pharmacology and Experimental Therapeutics 296(2), 312-321 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.4 |
| 分子式 | C20H21FN4O2 |
| CAS号 | 193551-21-2 |
| 稳定性 | ≥ 2 years |
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