| 货号 | 19136-500ug |
| 描述 | Lysine-specific demethylase 1 (LSD1) demethylates H3K4 and H3K9, resulting in transcriptional repression.1 It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370).2 ORY-1001 is an orally available, selective inhibitor of LSD1 (IC50< 20 nM).3,4 It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor cell load while increasing survival time in mouse models of AML.3,4 ORY-1001 is in clinical trials for cancer treatment.4 |
| 别名 | RG-6016; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Forneris, F.,Binda, C.,Vanoni, M.A., et al. Human histone demethylase LSD1 reads the histone code. The Journal of Biological Chemisty 280(50), 41360-41365 (2005). 2.Huang, J.,Sengupta, R.,Espejo, A.B., et al. p53 is regulated by the lysine demethylase LSD1. Nature 449, 105-108 (2007). 3.Maes, T.,Mascaró, C.,Ortega, A., et al. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. Epigenomics 7(4), 609-626 (2015). 4.Zheng, Y.C.,Yu, B.,Jiang, G.Z., et al. Irreversible LSD1 inhibitors: Application of tranylcypromine and its derivatives in cancer treatment. Current Topics in Medicinal Chemistry Feb, (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 303.3 |
| 分子式 | C15H22N2 • 2HCl |
| CAS号 | 1431326-61-2 |
| 稳定性 | ≥ 2 years |
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