O4I2
货号：
19135-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19135-1mg |
| 描述 | Octamer-binding transcription factor 3/4 (Oct3/4) is a transcription factor that has key roles in early embryogenesis and embryonic stem cell pluripotency.1,2 O4I2 is a potent inducer of Oct3/4 expression and translation in human cell lines, including embryonic kidney HEK293, embryonic placental NCCIT, and Oct-deficient HeLa cells.3 It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts. Through this action, O4I2 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Niwa, H.,Miyazaki, J.i., and Smith, A.G. Quantitative expression of Oct-¾ defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genetics 24(4), 372-376 (2000).
2.Takahashi, K.,Tanabe, K.,Ohnuki, M., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
3.Cheng, X.,Yoshida, H.,Raoofi, D., et al. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and derivatives are potent inducers of Oct3/4. Journal of Medicinal Chemistry 58(15), 5742-5750 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 282.7 |
| 分子式 | C12H11ClN2O2S |
| CAS号 | 165682-93-9 |
| 稳定性 | ≥ 2 years |
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