SBC-115076
货号：
19134-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19134-1mg |
| 描述 | Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with important roles in lipoprotein metabolism.1 PCSK9 overexpression in wild-type mice doubles plasma total cholesterol, possibly through acceleration of degradation of the LDL receptor (LDLR).1,2 SBC-115076 is an inhibitor of PCSK9 action that blocks LDLR degradation in HEK293T cells expressing PCSK9.3 Through this mechanism, submicromolar concentrations of SBC-115076 increase the uptake of LDL by liver cells in vitro.3 SBC-115076 is effective in vivo, lowering cholesterol levels in mice that are fed a high fat diet.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Maxwell, K.N.,Fisher, E.A., and Breslow, J.L. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proceedings of the National Academy of Sciences of the United States of America 102(6), 2069-2074 (2005).
2.Maxwell, K.N., and Breslow, J.L. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proceedings of the National Academy of Sciences of the United States of America 101(18), 7100-7105 (2004).
3.Abdel-Meguid, S.S.,Elshourbagy, N.,Meyers, H., et al. Anti-proprotein convertase subtilisin kexin type 9 (anti-pcsk9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases. PCT/US2014/022957, (2014).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 527.6 |
| 分子式 | C31H33N3O5 |
| CAS号 | 489415-96-5 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
