ESI-09
货号：
19130-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19130-1mg |
| 描述 | Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). ESI-09 is an inhibitor of Epac1 and Epac2 with IC50 values of 3.2 and 1.4 µM, respectively. It shows no activity against PKA at concentrations as high as 25 µM.1,2 ESI-09 has been shown to block Akt phosphorylation and insulin secretion in pancreatic β cells, as well as to block the migration of AsPC-1 and PANC-1 pancreatic cancer cells in vitro.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Almahariq, M.,Tsalkova, T.,Mei, F.C., et al. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Molecular Pharmacology 83(1), 122-128 (2013).
2.Zhu, Y.,Chen, H.,Boulton, S., et al. Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: Defining the ESI-09 "therapeutic window". Sci.Rep. 5:934, (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 330.8 |
| 分子式 | C16H15ClN4O2 |
| CAS号 | 263707-16-0 |
| 稳定性 | ≥ 2 years |
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