DG-172 (hydrochloride)
货号：
19128-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19128-1mg |
| 描述 | DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM).1 It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells.2 Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lieber, S.,Scheer, F.,Meissner, W., et al. (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. Journal of Medicinal Chemistry 55(6), 2858-2868 (2012).
2.Lieber, S.,Scheer, F.,Finkernagel, F., et al. The inverse agonist DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiation. Molecular Pharmacology 87(2), 162-173 (2015).
3.Adhikary, T.,Brandt, D.T.,Kaddatz, K., et al. Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion. Oncogene 32(44), 5241-5252 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 455.2 |
| 分子式 | C20H20BrN3 • 2HCl |
| CAS号 | 1361504-77-9 |
| 稳定性 | ≥ 2 years |
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