JW 74
货号：
19124-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19124-1mg |
| 描述 | Tankyrases (TNKS) are poly(ADP-ribose) polymerases (PARPs) that cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in a process known as poly(ADP-ribosyl)ation. TNKS have key roles in the Wnt signaling pathway as part of the β-catenin destruction complex. JW 74 is an inhibitor of the catalytic PARP domain of TNKS1/2 that blocks canonical Wnt signaling with an IC50 value of 790 nM.1,2 It increases the levels of Axin2 and decreases β-catenin levels in colorectal cancer (CRC) cells, leading to down-regulation of Wnt target genes.2 JW 74 inhibits the growth of CRC xenograft tumors in mice.2 JW 74 induces apoptosis and differentiation in osteosarcoma cell lines.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Stratford, E.W.,Daffinrud, J.,Munthe, E., et al. The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. Cancer Med. 3(1), 36-46 (2014).
2.Waaler, J.,Machon, O.,von Kries, J.P., et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Research 71(1), 197-205 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 456.5 |
| 分子式 | C24H20N6O2S |
| CAS号 | 863405-60-1 |
| 稳定性 | ≥ 2 years |
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