| 货号 | 19122-1mg |
| 描述 | NBI 31772 is a nonpeptide ligand that releases insulin-like growth factor-1 (IGF-1) from its binding protein (IGFBP; Kis = 1-24 nM for the six human subtypes of IGFBP).1,2 As the released IGF-1 is biologically active, NBI 31772 is used to assess the role of IGF-1 in cells and animals, including in neuron survival, skeletal muscle regeneration, and glucose homeostasis.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.De Ceuninck, F.,Caliez, A.,Dassencourt, L., et al. Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes. Arthirits Res.Ther. 6(5), R393-R403 (2004). 2.Liu, X.-J.,Xie, Q.W.,Zhu, Y.-F., et al. Identification of a nonpeptide ligand that releases bioactive insulin-like growth factor-I from its binding protein complex. J. Biol. Chem. 276(35), 32419-32422 (2001). 3.Hollis, E.R., II,Lu, P.,Blesch, A., et al. IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. Exp. Neurol. 215(1), 53-59 (2009). 4.Schertzer, J.D.,Gehrig, S.M.,Ryall, J.G., et al. Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. Am. J. Pathol. 171(4), 1180-1188 (2007). 5.Silha, J.V., and Murphy, L.J. The effects of the insulin-like growth factor-I aptamer, NBI-31772, on glucose homeostasis in the mouse. Can. J. Physiol. Pharmacol. 83(7), 557-563 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 341.3 |
| 分子式 | C17H11NO7 |
| CAS号 | 374620-70-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |