TY 52156
货号：
19119-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19119-1mg |
| 描述 | TY 52156 is a selective sphingosine-1-phosphate receptor 3 (SIP3) antagonist (Ki = 110 nM).1 It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4.1 TY 52156 has been shown to suppress FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts.1 TY 52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Murakami, A.,Takasugi, H.,Ohnuma, S., et al. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: Investigation based on a new S1P3 receptor antagonist. Molecular Pharmacology 77(4), 704-713 (2016).
2.Hirata, N.,Yamada, S.,Shoda, T., et al. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat.Commun. 5:4806, (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 364.3 |
| 分子式 | C18H19Cl2N3O |
| CAS号 | 934369-14-9 |
| 稳定性 | ≥ 2 years |
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