XAP044
货号：
19095-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19095-1mg |
| 描述 | XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM.1 This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gee, C.E.,Peterlik, D.,Neuhäuser, C., et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. The Journal of Biological Chemisty 289(16), 10975-10987 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.1 |
| 分子式 | C15H9IO4 |
| CAS号 | 196928-50-4 |
| 稳定性 | ≥ 2 years |
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