| 货号 | 19090-1mg |
| 描述 | UCM05 is an inhibitor of fatty acid synthase that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 µM for SK-BR-3 cells).1,2 It does not alter carnitine palmitoyltransferase 1 activity or induce weight loss in mice.1,2 UCM05 can reduce cleavage of poly(ADP-ribose) polymerase, phosphorylation of HER2, Akt, and ERK1/2, and growth of established xenografts in vivo.3 UCM05 also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division.4 |
| 别名 | G28UCM; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Puig, T.,Turrado, C.,Benhamú, B., et al. Novel inhibitors of fatty acid synthase with anticancer activity. Clinical Cancer Research 15(24), 7608-7615 (2009). 2.Turrado, C.,Puig, T.,García-Cárceles, J., et al. New synthetic inhibitors of fatty acid synthase with anticancer activity. Journal of Medicinal Chemistry 55(11), 5013-5023 (2012). 3.Puig, T.,Aguilar, H.,Cufi, S., et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Research 13(6), (2011). 4.Ruiz-Avila, L.B.,Huecas, S.,Artola, M., et al. Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ. ACS Chemical Biology 8(9), 2072-2083 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 464.4 |
| 分子式 | C24H16O10 |
| CAS号 | 1094451-90-7 |
| 稳定性 | ≥ 2 years |
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