| 货号 | 19071-1mg |
| 描述 | Heme oxygenases (HOs) convert protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin (Item No. 17161). Tin mesoporphyrin IX is a potent, competitive inhibitor of HO activity in vitro(Ki = 14 nM).1 It inhibits hepatic, renal, and splenic HO activity in vivo for extended periods of time.1 Tin mesoporphyrin IX blocks bilirubin production in vivo, decreasing HO activity in animal models of hyperbilirubinemia.1,2,3 Tin mesoporphyrin IX can be used to study the physiological roles of induced HO-1 expression in animal models.4,5,6 |
| 别名 | NSC 267099;SnMP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Drummond, G.S.,Galbraith, R.A.,Sardana, M.K., et al. Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism. Archives of Biochemistry and Biophysics 255(1), 64-74 (1987). 2.Drummond, G.S., and Kappas, A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proceedings of the National Academy of Sciences of the United States of America 78(10), 6466-6470 (1981). 3.Hamori, C.J.,Vreman, H.J., and Stevenson, D.K. Suppression of carbon monoxide excretion by zinc mesoporphyrin in adult Wistar rats: Evidence for potent in vivo inhibition of bilirubin production. Research Communications in Chemical Pathology and Pharmacology 62(1), 41-48 (1988). 4.Chen, T.m.,Li, J.,Fan, L., et al. Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal model of hypertensive myocardial infarction. International Journal of Molecular Sciences 14(2), 2684-2706 (2013). 5.Koeppen, A.H.,Dickson, A.C., and Smith, J. Heme oxygenase in experimental intracerebral hemorrhage: the benefit of tin-mesoporphyrin. Journal of Neuropathology and Experimental Neurology 63(6), 587-597 (2004). 6.Zhang, L.,Gan, Z.K.,Han, L.N., et al. Protective effect of heme oxygenase-1 on Wistar rats with heart failure through the inhibition of inflammation and amelioration of intestinal microcirculation. J.Geriatr.Cardiol. 12(4), 353-365 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 754.3 |
| 分子式 | C34H34Cl2N4O4Sn • 2H |
| CAS号 | 106344-20-1 |
| 稳定性 | ≥ 2 years |
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