| 货号 | 19056-10g |
| 描述 | 2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 µM.1 It does not affect xanthine oxidase-dependent or mitochondrial ROS generation.1 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells.1 It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation.2 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1.3 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 µM.4 |
| 别名 | 2-APT;ML-171;NSC 57951;NSC 169669; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gianni, D.,Taulet, N.,Zhang, H., et al. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chemical Biology 5(10), 981-993 (2010). 2.Vara, S.,Campanella, M., and Pula, G. The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner. British Journal of Pharmacology 168(1), 212-224 (2013). 3.Weaver, J.R.,Grzesik, W., and Taylor-Fishwick, D.A. Inhibition of NADPH oxidase-1 preserves β cell function. Diabetologia 58(1), 113-121 (2015). 4.Suzuki, H.,Hatano, N.,Muraki, Y., et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. American Journal of Physiology.Cell Physiology 307(4), C384-C394 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 241.3 |
| 分子式 | C14H11NOS |
| CAS号 | 6631-94-3 |
| 稳定性 | ≥ 2 years |
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