RB394
货号：
18909-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18909-1mg |
| 描述 | RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 µM and activates PPARγ with an EC50 of 0.3 µM.1 It is inactive at PPARδ and shows 29% activation of PPARα, relative to control, at 10 µM.1 RB394 is water soluble, orally bioavailable, and can be delivered through drinking water. In a two week in vivo pharmacokinetic study in mice, 30 mg/kg body weight in drinking water resulted in a final plasma concentration of ~3 µM.1 This coincided with upregulation of PPARγ target genes, as well as PPARα and PPARδ, in mouse livers.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Blöcher, R.,Lamers, C.,Wittman, S.K., et al. N-benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor γ modulators. Journal of Medicinal Chemistry 59(1), 61-81 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 409.4 |
| 分子式 | C21H22F3NO4 |
| CAS号 | 1830320-32-5 |
| 稳定性 | ≥ 2 years |
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