| 货号 | 18876-1mg |
| 描述 | NS 1619 is a calcium-dependent activator of large-conductance Ca2+-activated K+(BKCa) channels in vascular smooth muscle.1 It is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation.2,3 Studies suggest that activation of BKCa channels by NS 1619 can protect the cardiac muscle against pulmonary hypertension as well as ischemia and reperfusion injury in various animal models.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Edwards, G.,Niederste-Hollenberg, A.,Schneider, J., et al. Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle. British Journal of Pharmacology 113(4), 1538-1457 (1994). 2.Yamamura, H.,Ohi, Y.,Muraki, K., et al. BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery. British Journal of Pharmacology 132(4), 828-834 (2001). 3.Holland, M.,Langton, P.D.,Standen, N.B., et al. Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle. British Journal of Pharmacology 117(1), 119-129 (1996). 4.Revermann, M.,Neofitidou, S.,Kirschning, T., et al. Inhalation of the BKCa-opener NS1619 attenuates right ventricular pressure and improves oxygenation in the rat monocrotaline model of pulmonary hypertension. PLoS One 9(1), (2014). 5.Xu, W.,Liu, Y.,Wang, S., et al. Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science 298(5595), 1029-1033 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 362.2 |
| 分子式 | C15H8F6N2O2 |
| CAS号 | 153587-01-0 |
| 稳定性 | ≥ 2 years |
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