| 货号 | 18872-10g |
| 描述 | Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).1,2 As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitroandin vivo, thus preventing their growth and migration.3,4,5 Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.6 Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.7 |
| 别名 | NSC 184849;R 17635; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Seo, B.S.,Cho, S.Y.,Kang, S.Y., et al. Anthelmintic efficacy of methyl-5-benzoylbenzimidazole-2-carbamate(mebendazole) against multiple helminthic infections. Korean Journal of Parasitology 15(1), 11-16 (1977). 2.Morgan, U.M.,Reynoldson, J.A., and Thompson, R.C.A. Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro. Antimicrobial Agents and Chemotherapy 37(2), 328-331 (1993). 3.Doudican, N.,Rodriguez, A.,Osman, I., et al. Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells. Molecular Cancer Research 6(8), 1308-1315 (2008). 4.Mukhopadhyay, T.,Sasaki, J.i.,Ramesh, R., et al. Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo. Clinical Cancer Research 8(9), 2963-2969 (2002). 5.Sasaki, J.i.,Ramesh, R.,Chada, S., et al. The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells. Molecular Cancer Therapeutics 1(13), 1201-1209 (2016). 6.Larsen, A.R.,Bai, R.Y.,Chung, J.H., et al. Repurposing the antihelmintic mebendazole as a hedgehog inhibitor. Molecular Cancer Therapeutics 14(1), 3-13 (2015). 7.Aleyasin, H.,Karuppagounder, S.S.,Kumar, A., et al. Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin. Antioxidants & Redox Signaling 22(2), 121-134 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 295.3 |
| 分子式 | C16H13N3O3 |
| CAS号 | 31431-39-7 |
| 稳定性 | ≥ 2 years |
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