Tolazoline (hydrochloride)
货号：
18865-5g 基本售价：
350.0 元 规格：
5 g
产品信息
概述| 货号 | 18865-5g |
| 描述 | Tolazoline is a competitive α1- and α2-adrenergic receptor antagonist (pKis~6.5) well-known for its peripheral vasodilator effects in animal models.1,2 It also is reported to produce histamine-like effects that are sensitive to histamine H2-receptor antagonism in whole animals and a variety of isolated tissues.3 Certain α2-adrenergic receptor antagonists, including tolazoline, are most commonly used in veterinary medicine as reversal agents for the sedative effects of α2-adrenergic receptor agonists such as xylazine (Item No. 14113).2 |
| 别名 | Arterodyl;Priscoline; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Radwanska, A., and Kaliszan, R. Comparative analysis of effects of imidazoline drugs on isolated rat heart atria. Journal of Physiology and Pharmacology 44(1), 73-87 (1993).
2.Schwartz, D.D., and Clark, T.P. Selectivity of atipamezole, yohimbine and tolazoline for alpha-2 adrenergic receptor subtypes: Implications for clinical reversal of alpha-2 adrenergic receptor mediated sedation in sheep. J. Vet. Pharmacol. Ther. 21(5), 342-347 (1998).
3.Kenakin, T.P., and Angus, J.A. The histamine-like effects of tolazoline and clonidine: Evidence against direct activity at histamine receptors. Journal of Pharmacology and Experimental Therapeutics 219(2), 474-480 (1981).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 196.7 |
| 分子式 | C10H12N2 • HCl |
| CAS号 | 59-97-2 |
| 稳定性 | ≥ 2 years |
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