PHPS1
货号：
18856-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18856-1mg |
| 描述 | PHPS1 is a cell-permeable, phosphotyrosine mimetic that inhibits the Src homology region 2 domain-containing phosphatase (SHP)-2 (IC50 = 2.1 µM; Ki = 0.73 µM).1 It is selective for SHP-2, inhibiting ECPTP, PTP1B, SHP-1, and mycobacterium MptpA at relatively higher concentrations (IC50s = 5.4, 19, 30, and 39 µM, respectively).1 PHPS1 has been shown to inhibit SHP-2-dependent cellular signaling and tumor cell colony formation.1 |
| 别名 | Phenylhydrazonopyrazolone sulfonate 1;Protein Tyrosine Phosphatase Inhibitor V;PTP Inhibitor V; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hellmuth, K.,Grosskopf, S.,Lum, C.T., et al. Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proceedings of the National Academy of Sciences of the United States of America 105(20), 7275-7280 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 465.4 |
| 分子式 | C21H15N5O6S |
| CAS号 | 314291-83-3 |
| 稳定性 | ≥ 2 years |
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