| 货号 | 18813-10mg |
| 描述 | Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1 Rosuvastatin is an HMG-CoA reductase inhibitor (IC50 = 5 nM).2,1 It is a fully-synthetic inhibitor that is designed to maximize the points of contact with, and inhibition of, HMG-CoA reductase.2 Rosuvastatin reduces low-density lipoprotein and C-reactive protein and increases high-density lipoprotein in clinical trials.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tobert, J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nature Reviews.Drug Discovery 2(7), 517-526 (2003). 2.Istvan, E.S., and Deisenhofer, J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292, 1160-1164 (2001). 3.Asztalos, B.F.,Maulf, F.L.,Dallal, G.E., et al. Comparison of the effects of high doses of Rosuvastatin versus Atorvastatin on the subpopulations of high-density lipoproteins. American Journal of Cardiology 99, 681-685 (2007). 4.Rubba, P.,Marotta, G., and Gentile, M. Efficacy and safety of rosuvastatin in the management of dyslipidemia. Vascular Health and Risk Management 5(1), 343-352 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 501.6 |
| 分子式 | C22H28FN3O6S • 1/2Ca |
| CAS号 | 147098-20-2 |
| 稳定性 | ≥ 2 years |
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