SB-207266
货号：
18778-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18778-1mg |
| 描述 | The indole derivative SB-207266 is a selective and potent antagonist of the serotonin (5-HT) receptor 5-HT4 with a pA2 value of 10.6 ± 0.1.1,2 In COS7 cells, 100 nM SB-207266 inhibited 5-HT4 responses to 5-HT and reduced basal agonist-independent cAMP production.3 In several animal models, low concentrations of SB-207266 blocked exogenous 5-HT-mediated sensitization of intestinal peristalsis.1,4,5 In a dog model, SB-207266 (0.1–100 pg/kg) dose-dependently reduced responses to 5-HT, with an ID50 value of 1.3 pg/kg.1 SB-206226 (0.5 mg/kg/24 h) improved cardiac function in a rat model of congestive heart failure.6 |
| 别名 | Piboserod; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wardle, K.A.,Bingham, S.,Ellis, E.S., et al. Selective and functional 5-hydroxytryptamine4 receptor antagonism by SB 207266. Br. J. Pharmacol. 118(3), 665-670 (1996).
2.Claeysen, S.,Sebben, M.,Bécamel, C., et al. Pharmacological properties of 5-Hydroxytryptamine4 receptor antagonists on constitutively active wild-type and mutated receptors. Mol. Pharmacol. 58(1), 136-144 (2000).
3.Birkeland, J.A.K.,Sjaastad, I.,Brattelid, T., et al. Effects of treatment with a 5-HT4 receptor antagonist in heart failure. Br. J. Pharmacol. 150(2), 143-152 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 369.5 |
| 分子式 | C22H31N3O2 |
| CAS号 | 152811-62-6 |
| 稳定性 | ≥ 2 years |
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