Altiratinib
货号：
18777-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18777-1mg |
| 描述 | Altiratinib is a multiple kinase inhibitor, blocking Met, Tie2, VEGF2, TrkA, TrkB, and TrkC with IC50 values of 2.7, 8.0, 9.2, 0.85, 4.6, and 0.83 nM, respectively.1 It also inhibits several mutant Met isoforms at nanomolar concentrations. Altiratinib inhibits the proliferation of several cancer cell lines in vitro and blocks capillary tube formation by HMVEC cells.1 It is orally bioavailable and penetrates the blood brain barrier, suppressing the growth of subcutaneous and intracerebroventricular xenograft tumors in mice.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Smith, B.D.,Kaufman, M.D.,Leary, C.B., et al. Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2. Mol. Cancer Ther. 14(9), 2023-2034 (2015).
2.Piao, Y.,Park, S.Y.,Henry, V., et al. Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models. Neuro. Oncol. 18(9), 1230-1241 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 510.5 |
| 分子式 | C26H21F3N4O4 |
| CAS号 | 1345847-93-9 |
| 稳定性 | ≥ 2 years |
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