Doxofylline
货号：
18746-1g 基本售价：
350.0 元 规格：
1 g
产品信息
概述| 货号 | 18746-1g |
| 描述 | Doxofylline is a methylxanthine bronchodilator that has been examined in clinical trials involving patients with either bronchial asthma or chronic obstructive pulmonary disease.1 Its mechanism of action is related to its ability to inhibit phosphodiesterase activity and, thus, increase cAMP.2 Compared to other xanthine derivatives, which have direct arrhythmogenic effects, doxofylline demonstrates decreased affinity towards adenosine A1 and A2 receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Akram, M.F.,Nasiruddin, M.,Ahmad, Z., et al. Doxofylline and theophylline: A comparative clinical study. J.Clin.Diagn.Res. 6(10), 1681-1684 (2012).
2.Shukla, D.,Chakraborty, S.,Singh, S., et al. Doxofylline: A promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin.Pharmacother. 10(14), 2343-2356 (2009).
3.Dini, F.L., and Cogo, R. Doxofylline: A new generation xanthine bronchodilator devoid of major cardiovascular adverse effects. Current Medical Research and Opinion 16(4), 258-268 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 266.3 |
| 分子式 | C11H14N4O4 |
| CAS号 | 69975-86-6 |
| 稳定性 | ≥ 2 years |
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