| 货号 | 18723-1mg |
| 描述 | Oxyphenbutazone is a metabolite of phenylbutazone (Item No. 70400). Both compounds were identified as having anti-inflammatory effects in early studies, and, as a result, are considered NSAIDs.1 Interestingly, the effects of the two compounds in animal models differ, with phenylbutazone having anti-inflammatory effects in rheumatic diseases and oxyphenbutazone reducing edema in certain types of acute inflammation.1 Oxyphenbutazone is a poor inhibitor of prostaglandin synthesis, but, like other NSAIDs, it inhibits organic anion transporter 1 (Ki = 32 µM).2,3 It inhibits the growth of MH60/BSF-2 cells induced by IL-6 (IC50 = 7.5 µM).4 Oxyphenbutazone stimulates neurite outgrowth at 1.5 µM and sensitizes M. tuberculosis to antimicrobials.5,6 |
| 别名 | G 27202;p-Hydroxyphenylbutazone;NSC 526053;Ro 04-4410; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wilhelmi, G. Newer pharmacological data on oxyphenbutazone. Japanese Journal of Pharmacology 15(2), 187-198 (1965). 2.Gryglewski, R., and Vane, J.R. The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs. British Journal of Pharmacology 45(1), 37-47 (1972). 3.Apiwattanakul, N.,Sekine, T.,Chairoungda, A., et al. Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Molecular Pharmacology 55(5), 847-854 (2015). 4.Kang, B.S.,Chung, E.Y.,Yun, Y.P., et al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biological and Pharmaceutical Bullentin 24(6), 701-703 (2001). 5.Yeyeodu, S.T.,Witherspoon, S.M.,Gilyazova, N., et al. A rapid, inexpensive high throughput screen method for neurite outgrowth. Curr.Chem.Genomics 4, 74-83 (2010). 6.Gold, B.,Pingle, M.,Brickner, S.J., et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proceedings of the National Academy of Sciences of the United States of America 109(40), 16004-16011 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 324.4 |
| 分子式 | C19H20N2O3 |
| CAS号 | 129-20-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |