| 货号 | 18719-1mg |
| 描述 | Phosphatase of regenerating liver 3 (PRL-3; also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases.1,2 It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay.1 PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin β1 and modulates VEGF-mediated endothelial cell migration.3,4 It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines.5,6 |
| 别名 | BR-1;P0108;Phosphatase of Regenerating Liver 3 Inhibitor;PTP4A3 Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ahn, J.H.,Kim, S.J.,Park, W.S., et al. Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. Bioorganic & Medicinal Chemistry Letters 16(11), 2996-2999 (2006). 2.Min, G.,Lee, S.K.,Kim, H.N., et al. Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells. Bioorganic & Medicinal Chemistry Letters 23(13), 3769-3774 (2013). 3.Tian, W.,Qu, L.,Meng, L., et al. Phosphatase of regenerating liver-3 directly interacts with integrin β1 and regulates its phosphorylation at tyrosine 783. BMC Biochemistry 13:22, (2012). 4.Zimmerman, M.W.,McQueeney, K.E.,Isenberg, J.S., et al. Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. The Journal of Biological Chemisty 289(9), 5904-5913 (2014). 5.Ooki, A.,Yamashita, K.,Kikuchi, S., et al. Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer. BMC Cancer 11:122, (2011). 6.Zhou, J.,Bi, C.,Chng, W.J., et al. PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy. PLoS One 6(5), (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 485.2 |
| 分子式 | C17H11Br2NO2S2 |
| CAS号 | 893449-38-2 |
| 稳定性 | ≥ 2 years |
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