| 货号 | 18713-1mg |
| 描述 | Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like).1L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 µM for PLAP and NSAP, respectively).1,2,3,4 While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition.3L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.5,6 |
| 别名 | (-)-p-Bromotetramisole;L-para-Bromotetramisole; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Denier, C.C.,Brisson-Lougarre, A.A.,Biasini, G.G., et al. Kinetic comparison of tissue non-specific and placental human alkaline phosphatases expressed in baculovirus infected cells: Application to screening for Down’s syndrome. BMC Biochemistry 3:2, (2002). 2.Van Belle, H.,De Broe, M.E., and Wieme, R.J. L-p-Bromotetramisole, a new reagent for use in measuring placental or intestinal isoenzymes of alkaline phosphatase in human serum. Clinical Chemistry 23(3), 454-459 (1977). 3.Sakiyama, T.,Robinson, J.C., and Chou, J.Y. Characterization of alkaline phosphatases from human first trimester placentas. The Journal of Biological Chemisty 254(3), 935-938 (1979). 4.Doellgast, G.J., and Meis, P.J. Use of specific inhibitors to discriminate alkaline phosphatase isoenzymes originating from human liver, placenta and intestine: Absensce of meconial alkaline phosphatase in maternal serum. Clinical Chemistry 25(7), 1230-1233 (1979). 5.Fukami, Y., and Lipmann, F. Purification of a specific reversible tyrosine-O-phosphate phosphatase. Proceedings of the National Academy of Sciences of the United States of America 79(14), 4275-4279 (1982). 6.Yingst, D.R.,Davis, J., and Schiebinger, R. Inhibitors of tyrosine phosphatases block angiotensin II inhibition of Na(+) pump. European Journal of Pharmacology 461(1), 49-52 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 373.2 |
| 分子式 | C11H11BrN2S • C2H2O4 |
| CAS号 | 62284-79-1 |
| 稳定性 | ≥ 2 years |
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