| 货号 | 18682-10g |
| 描述 | Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals.1 Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures.2,3 PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABAA receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABAAreceptor.4,5 |
| 别名 | α,β-Cyclopentamethylenetetrazole;1,5-Pentamethylenetetrazole;PTZ;NSC 5729;NSC 66489; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Löscher, W. Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure 20(5), 359-368 (2011). 2.Snider, N.T.,Nast, J.A.,Tesmer, L.A., et al. A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist. Molecular Pharmacology 75(4), 965-972 (2009). 3.Kaufmann, K.,Romaine, I.M.,Days, E., et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem.Neurosci. 4(9), 1278-1286 (2013). 4.Chaix, Y.,Ferraro, T.N.,Lapouble, E., et al. Chemoconvulsant-induced seizure susceptibility: Toward a common genetic basis? Epilepsia 48 Suppl 5, 48-52 (2007). 5.White, H.S. Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia 38 Suppl 1, S9-S17 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 138.2 |
| 分子式 | C6H10N4 |
| CAS号 | 54-95-5 |
| 稳定性 | ≥ 2 years |
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