L-755,507
货号：
18629-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18629-1mg |
| 描述 | L-755,507 is a partial agonist of β3-adrenergic receptors (EC50 = 0.43 nM).1 It displays more than 440-fold selectivity for β3- over β1- and β2-adrenoceptors (EC50s = 580 and >10,000 nM, respectively).1 At 5 µM, this compound has been used to enhance CRISPR-mediated homology-directed repair efficiency by 3-fold for large fragment insertions and by 9-fold for point mutations.2 L-755,507 has been used to identify signaling pathways activated through β3-adrenergic receptors.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Parmee, E.R.,Ok, H.O.,Candelore, M.R., et al. Discovery of L-755,507: A subnanomolar humanβ3 adrenergic receptor agonist. Bioorganic & Medicinal Chemistry Letters 8(9), 1107-1112 (1998).
2.Yu, C.,Liu, Y.,Ma, T., et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16(2), 142-147 (2015).
3.Sato, M.,Hutchinson, D.S.,Evans, B.A., et al. The β3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human β3-adrenoceptor. Molecular Pharmacology 74(5), 1417-1428 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 584.7 |
| 分子式 | C30H40N4O6S |
| CAS号 | 159182-43-1 |
| 稳定性 | ≥ 2 years |
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