| 货号 | 18628-10mg |
| 描述 | Carazolol is a high-affinity, lipophilic, non-selective ligand of the β-adrenergic receptors (Kis = 0.114 and 0.4 nM for β2- and β3-adrenoceptors, respectively).1,2,3 It acts as a receptor antagonist (beta blocker) or inverse agonist for β1 and β2 receptors but functions as an agonist at the β3-adrenergic receptor.2,3,4,5 |
| 别名 | BM 51052;(±)-Carazolol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sabio, M.,Jones, K., and Topiol, S. Use of the X-ray structure of the β2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds. Bioorganic & Medicinal Chemistry Letters 18(20), 5391-5395 (2008). 2.Piétri-Rouxel, F.,Lenzen, G.,Kapoor, A., et al. Molecular cloning and pharmacological characterization of the bovine β3-adrenergic receptor. European Journal of Biochemistry 230(1), 350-358 (2015). 3.Bang, I., and Choi, H.J. Structural features of β2 adrenergic receptor: Crystal structures and beyond. Molecules and Cells 38(2), 105-111 (2015). 4.Plazinska, A.,Plazinski, W., and Jozwiak, K. Agonist binding by the β2-adrenergic receptor: An effect of receptor conformation on ligand association-dissociation characteristics. Eur.Biophys.J. 44(3), 149-163 (2015). 5.Méjean, A.,Guillaume, J.L., and Strosberg, A.D. Carazolol: A potent, selective β3-adrenoceptor agonist. European Journal of Pharmacology 291(3), 359-366 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 298.4 |
| 分子式 | C18H22N2O2 |
| CAS号 | 57775-29-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |