| 货号 | 18601-5g |
| 描述 | Tyramine is a naturally-occurring monoamine derived from tyrosine that is produced endogenously or can be obtained from certain foods. It is a trace amine that activates trace amine-associated receptor 1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively).1,2,3 Tyramine also inhibits the release of norepinephrine and dopamine (IC50s = 40.6 and 119 nM, respectively).4 It is metabolized by monoamine oxidase A.5 |
| 别名 | 2-(4-Hydroxyphenyl)ethylamine;NSC 249188;p-Tyramine;Uteramine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Reese, E.A.,Bunzow, J.R.,Arttamangkul, S., et al. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. Journal of Pharmacology and Experimental Therapeutics 321(1), 178-186 (2007). 2.Zucchi, R.,Chiellini, G.,Scanlan, T.S., et al. Trace amine-associated receptors and their ligands. British Journal of Pharmacology 149(8), 967-978 (2006). 3.Maguire, J.J.,Parker, W.A.E.,Foord, S.M., et al. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacological Reviews 61(1), (2009). 4.Rothman, R.B.,Baumann, M.H.,Dersch, C.M., et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Science 39(1), 32-41 (2001). 5.Sjöqvist, F. Psychotropic drugs (2) interaction between monoamine oxidase (MAO) inhibitors and other substances. Proc.R.Soc.Med. 58(11 pt. 2), 967-978 (1965). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 137.2 |
| 分子式 | C8H11NO |
| CAS号 | 51-67-2 |
| 稳定性 | ≥ 2 years |
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