CRT5
货号：
18532-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18532-1mg |
| 描述 | Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively).1 It has little effect on a panel of additional kinases when given at 1 µM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation.1 It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.1 |
| 别名 | CRT0066051; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Evans, I.M.,Bagherzadeh, A.,Charles, M., et al. Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochemistry Journal 429(3), 565-572 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 454.6 |
| 分子式 | C28H30N4O2 |
| CAS号 | 1034297-58-9 |
| 稳定性 | ≥ 2 years |
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