ML-178
货号：
18527-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18527-1mg |
| 描述 | Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through four of the S1P receptors (S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8). Binding of S1P to S1P4 activates ERK, MAPK, and PLC downstream signal transduction pathways. ML-178 activates S1P4 with an EC50 value of 46.3 nM and is inactive against S1P1, S1P2, S1P3, and S1P5(EC50s = >50 µM) and has no effect against a panel of additional receptors, transporters, and ion channels.1 |
| 别名 | CID 44620892;CYM 50179;SID 87544119; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Guerrero, M.,Urbano, M.,Velaparthi, S., et al. Probe development efforts to identify novel agonists of the sphingosine 1-phosphate receptor 4 (S1P4). (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 441.9 |
| 分子式 | C13H9Br2Cl2NO2 |
| CAS号 | 1355026-47-9 |
| 稳定性 | ≥ 2 years |
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