NBI 35965 (mesylate)
货号：
18524-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18524-1mg |
| 描述 | Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. NBI 35965 is a selective CRF receptor 1 (CRF1) antagonist with a Ki value of 4 nM.1,2 It does not inhibit CRF2(Ki = >10,000 nM).2 NBI 35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro(pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo.3 In animal models of stress, NBI 35965 administration produces anxiolytic effects.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hoare, S.R.J.,Sullivan, S.K.,Ling, N., et al. Mechanism of corticotropin-releasing factor type I receptor regulation by nonpeptide antagonists. Molecular Pharmaceutics 63(3), 751-765 (2003).
2.Million, M.,Grigoriadis, D.E.,Sullivan, S., et al. A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Research 985, 32-42 (2003).
3.Gross, R.S.,Guo, Z.,Dyck, B., et al. Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists. Journal of Medicinal Chemistry 48, 5780-5793 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 497.4 |
| 分子式 | C21H22Cl2N4 • CH3SO3H |
| CAS号 | 603151-83-3 |
| 稳定性 | ≥ 2 years |
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