PTP Inhibitor IV
货号：
18458-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18458-1mg |
| 描述 | Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. PTP inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido phosphate mimetic that acts as a reversible, competitive, and active-site directed inhibitor of SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ (IC50s = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM, respectively).1 |
| 别名 | Protein Tyrosine Phosphatase Inhibitor IV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huang, P.,Ramphal, J.,Wei, J., et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioor.Med.Chem. 11, 1835-1849 (2003).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 608.6 |
| 分子式 | C26H26F6N2O4S2 |
| CAS号 | 329317-98-8 |
| 稳定性 | ≥ 2 years |
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