| 货号 | 18456-5mg |
| 描述 | Valnoctamide is an isomer of the valproic acid amide, valpromide. It has been marketed as an anxiolytic and sedative compound and suppresses neuropathic pain.1,2 Unlike valpromide, valnoctamide is not metabolized to its acid form, valnoctic acid, in vivo and has no teratogenicity.1 It abolishes the activity of myo-inositol-1-phosphate synthase in human brain crude homogenates (Ki = 0.18 mM).3 Valnoctamide suppresses electrographic seizures in animal models of status epilepticus, suggesting potential applications in managing epilepsy.4 |
| 别名 | NSC 32363;NSC 34092;Valmethamide;Valoctamidum; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rogawski, M.A. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Research 69(3), 273-294 (2006). 2.Winkler, I.,Blotnik, S.,Shimshoni, J., et al. Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain. British Journal of Pharmacology 146, 198-208 (2005). 3.Shaltiel, G.,Mark, S.,Kofman, O., et al. Effect of valproate derivatives on human brain myo-inositol-1-phosphate (MIP) synthase activity and amphetamine-induced rearing. Pharmacological Reports 59(4), 402-407 (2007). 4.Spampanato, J., and Dudek, F.E. Valnoctamide enhances phasic inhibition: A potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus. Epilepsia 55(9), e94-e98 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 143.2 |
| 分子式 | C8H17NO |
| CAS号 | 4171-13-5 |
| 稳定性 | ≥ 2 years |
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