| 货号 | 18431-1mg |
| 描述 | Neuroactive steroids (widely known as neurosteroids), including progesterone (Item No.15876) and several of its metabolites, have been shown to mediate some of their physiological effects though a modulatory site on GABAA receptors.1 Epiallopregnanolone is a metabolite of progesterone and a 3β-isomer of allopregnanolone (Item No.16930), which has been shown to enhance GABA neurotransmission.2,3 Epiallopregnanolone is inactive as a GABAA receptor modulator and is used as a control substance to examine GABAneurotransmission.4 |
| 别名 | 5α-Pregnan-20-one;3β,21-dihydroxy-5α-Pregnan-20-one;3β,5α-Tetrahydrodeoxycorticosterone;3β,5α-Tetrahydroprogesterone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Belelli, D.,Herd, M.B.,Mitchell, E.A., et al. Neuroactive steroids and inhibitory neurotransmission: Mechanisms of action and physiological relevance. Neuroscience 138, 821-829 (2006). 2.Reddy, D.S. Neurosteroids: Endogenous role in the human brain and therapeutic potentials. Progress in Brain Research 186, 113-137 (2010). 3.Johnston, G.A.R.,Chebib, M.,Hanrahan, J.R., et al. Neurochemicals for the investigation of GABAC receptors. Neurochemical Research 35(12), 1970-1977 (2010). 4.Lambert, J.J.,Peters, J.A.,Harney, S.C., et al. Steroid modulation of GABAA receptors. Pharmacology of GABA and Glycine Neurotransmission 150, 117-140 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 334.5 |
| 分子式 | C21H34O3 |
| CAS号 | 567-01-1 |
| 稳定性 | ≥ 2 years |
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