| 货号 | 18425-500mg |
| 描述 | Vitamin B12 is a water-soluble vitamin with roles in brain and nervous system functioning and blood formation through regulation of DNA synthesis, cellular metabolism, fatty acid metabolism, and amino acid metabolism.1 It belongs to the corrinoid group of compounds, which contain a corrin macrocycle, and is produced only by certain bacteria and archaea.2 Reference to vitamin B12 usually encompasses a group of cobalt-containing compounds (or cobalamins), which include cyanocobalamin, hydroxocobalamin, 5-deoxyadenosylcobalamin (AdoB12), and methylcobalamin (MeB12). These forms serve as cofactors in isomerase-, methyltransferase-, and dehalogenase-catalyzed reactions.3 For example, methylmalonyl coenzyme A mutase acts on AdoB12 to convert methylmalonyl-CoA to succinyl-CoA, an important step before entry into the Kreb’s cycle. Additionally, methionine synthase uses MeB12 to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine to generate tetrahydrofolate and methionine, which is important for DNA synthesis.4 |
| 别名 | Cobalamin;NSC 80365; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.. Vitamin B12. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline 306-356 (1998). 2.Moore, S.J.,Lawrence, A.D.,Biedendieck, R., et al. Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). Proc. Natl. Acad. Sci. USA 110(37), 14906-14911 (2015). 3.Banerjee, R., and Ragsdale, S.W. The many faces of vitamin B12: Catalysis by cobalamin-dependent enzymes. Annual Reviews of Biochemistry 72, 209-247 (2003). 4.Ragsdale, S.W. Catalysis of methyl group transfers involving tetrahydrofolate and B12. Vitamins and Hormones 79, 293-324 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 1355.4 |
| 分子式 | C63H88CoN14O14P |
| CAS号 | 68-19-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |