SR9243
货号：
18420-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18420-1mg |
| 描述 | The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors.1 They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9243 is a cell-permeable LXR inverse agonist that induces LXR-corepressor interaction at nanomolar concentrations.2 It reduces cancer cell viability (IC50 values range from 15 to 104 nM) without cytotoxicity against non-malignant cells.2 SR9243 disrupts the Warburg effect in cancer cells, suppressing the expression of glycolytic and lipogenic genes and reducing glycolytic metabolites and lipid production. It is effective in vivo, blocking glycolytic and lipogenic gene expression and inducing apoptosis in colon cancer xenografts without inducing weight loss in mice.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gabbi, C.,Warner, M., and Gustafsson, J.Ä. Action mechanisms of liver X receptors. Biochemical and Biophysical Research Communications 446(3), 647-650 (2014).
2.Flaveny, C.A.,Griffett, K.,El-Gendy, B.E.D.M., et al. Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell 28, 42-56 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 626.6 |
| 分子式 | C31H32BrNO4S2 |
| CAS号 | 1613028-81-1 |
| 稳定性 | ≥ 2 years |
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