PSI-6206
货号：
18391-50mg 基本售价：
350.0 元 规格：
50 mg
产品信息
概述| 货号 | 18391-50mg |
| 描述 | PSI-6206 is the deaminated derivative of PSI-6130, a selective inhibitor of hepatitis C virus (HCV) replication that targets the NS5B polymerase.1,2 PSI-6206, itself, does not inhibit HCV replication in the HCV subgenomic replicon assay.1,2 However, its triphosphate form, RO 2433-TP, does inhibit RNA synthesis by HCV polymerase (IC50 = 1.19 µM for inhibition of RNA synthesis activity of HCV replicase).1,2 |
| 别名 | GS-331007;RO 2433; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Murakami, E.,Niu, C.,Bao, H., et al. The mechanism of action of β-D-2-deoxy-2-fluoro-2-C-methylcytidine involves a second metabolic pathway leading to β-D-2-deoxy-2-fluoro-2-C-methyluridine 5-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. Antimicrobial Agents and Chemotherapy 52(2), 458-464 (2008).
2.Ma, H.,Jiang, W.R.,Robledo, N., et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor β-D-2-Deoxy-2-fluoro-2-C-methylcytidine (PSI-6130) and identification of a novel active 5-triphosphate species. The Journal of Biological Chemisty 282(41), 29812-29820 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 260.2 |
| 分子式 | C10H13FN2O5 |
| CAS号 | 863329-66-2 |
| 稳定性 | ≥ 2 years |
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