PF-06447475
货号：
18375-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18375-1mg |
| 描述 | PF-06447475 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 3 nM), an enzyme genetically linked to Parkinsons disease that interacts with parkin, a ligase whose loss of function leads to dopaminergic cell death.1 PF-06447475 has been shown to attenuate α-synuclein-induced dopaminergic neurodegeneration and neuroinflammation in G2019S-LRRK2-expressing rats.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Henderson, J.L.,Kormos, B.L.,Hayward, M.M., et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J.Med.Chem 58(1), 419-432 (2015).
2.Daher, J.P.L.,Abdelmotilib, H.A.,Hu, X., et al. Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration. J.Bio.Chem. 290(32), 19433-19444 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 305.3 |
| 分子式 | C17H15N5O |
| CAS号 | 1527473-33-1 |
| 稳定性 | ≥ 2 years |
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