Temocapril (hydrochloride)
货号：
18241-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 18241-5mg |
| 描述 | Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Temocapril is a prodrug of the ACE inhibitor, temocaprilat (IC50 = 3.6 and 7.6 nM in isolated rat lung and aorta, respectively).1 Upon oral administration it is rapidly deesterified to the active form, which remains long acting until excreted in bile and urine.1 In clinical trials, it has been used to reduce blood pressure, improve endothelial dysfunction, and prevent vascular remodeling, as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yasunari, K.,Maeda, K.,Nakamura, M., et al. Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile. Cardiovascular Drug Reviews 22(3), 189-198 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 513.1 |
| 分子式 | C23H28N2O5S2 • HCl |
| CAS号 | 110221-44-8 |
| 稳定性 | ≥ 2 years |
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