| 货号 | 18227-1mg |
| 描述 | Ciclesonide (CIC) is a corticosteroid prodrug that is converted to its active form, desisobutyryl-CIC (des-CIC), by cellular esterases.1,2 Des-CIC is a glucocorticoid receptor agonist (Ki = 0.31 nM).3 Inhaled corticosteroids, including CIC, are used to ameliorate symptoms of airway inflammatory diseases, such as asthma, allergic rhinitis, and chronic obstructive pulmonary disease.2,4,5,6 |
| 别名 | CIC;RPR 251526; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mutch, E.,Nae, R.,McCracken, N., et al. The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue. Biochemical Pharmacology 15(73), 1657-1664 (2007). 2.Derendorf, H.,Nave, R.,Drollmann, A., et al. Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma. European Respiratory Journal 28, 1042-1050 (2006). 3.Belvisi, M.G.,Bundschuh, D.S.,Stoeck, M., et al. Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma. Journal of Pharmacology and Experimental Therapeutics 314(2), 568-574 (2005). 4.Schmidt, B.M.,Timmer, W.,Georgens, A.C., et al. The new topical steroid ciclesonide is effective in the treatment of allergic rhinitis. Journal of Clinical Pharmacology 39(10), 1062-1069 (1999). 5.Postma, D.S.,Sevette, C.,Martinat, Y., et al. Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening. European Respiratory Journal 17, 1083-1088 (2001). 6.De Coster, D.A., and Jones, M. Tailoring of corticosteroids in COPD management. Curr.Respir.Care Rep. 3, 121-132 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 540.7 |
| 分子式 | C32H44O7 |
| CAS号 | 126544-47-6 |
| 稳定性 | ≥ 2 years |
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