RS 102895 (hydrochloride)
货号：
18207-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18207-1mg |
| 描述 | The chemokine CCL2, also known as monocyte chemotactic protein-1 (MCP-1), stimulates leukocyte chemotaxis to sites of inflammation via signaling through the MCP-1 receptor, CCR2. RS 102895 is a spiropiperidine compound that acts as a CCR2 antagonist (IC50 = 0.36 µM).1 It inhibits the related CCR1 receptor with an IC50 value of 17.8 µM and inhibits adrenergic α1a, α1d, and 5HT1A receptors with IC50 values of 0.13, 0.32, and 47 µM, respectively.1 RS 102895 prevents chemotaxis of THP-1 cells (IC50 = 1.7 µM) when MCP-1 is presented as a chemoattractant.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mirzadegan, T.,Diehl, F.,Ebi, B., et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: Binding to a common chemokine receptor motif within the helical bundle. The Journal of Biological Chemisty 275(33), 25562-25571 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 426.9 |
| 分子式 | C21H21F3N2O2 • HCl |
| CAS号 | 1173022-16-6 |
| 稳定性 | ≥ 2 years |
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