Tolmetin (sodium salt hydrate)
货号：
18195-1g 基本售价：
350.0 元 规格：
1 g
产品信息
概述| 货号 | 18195-1g |
| 描述 | Tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 µM, respectively.1 It also inhibits aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Warner, T.D.,Giuliano, F.,Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proceedings of the National Academy of Sciences of the United States of America 96(13), 7563-7568 (1999).
2.Zheng, X.,Zhang, L.,Zhai, J., et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase. FEBS Letters 586(1), 55-59 (2012).
3.Flanagan, J.U.,Yosaatmadja, Y.,Teague, R.M., et al. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PLoS One 7(8), 1-16 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 315.3 |
| 分子式 | C15H14NO3 • Na [2H2O] |
| CAS号 | 64490-92-2 |
| 稳定性 | ≥ 2 years |
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