| 货号 | 18189-5g |
| 描述 | Dipyridamole is a phosphodiesterase (PDE)5A inhibitor (IC50 = 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosine via red blood cells.1,2 It also scavenges the free radicals that inactivate cyclooxygenase, leading to the inhibition of platelet activation and thrombin generation.1 Dipyridamole has been used in combination with aspirin (Item No. 70260) to prevent stroke and other cardiovascular events.3 Dipyridamole has also been shown to inhibit PDE11A with an IC50 value of 370 nM and equilibrative nucleoside transporter 1 with a Ki value of 8.18 nM.4,5 |
| 别名 | NSC 515776;NSC 619103; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rondina, M.T., and Weyrich, A.S. Targeting phosphodiesterases in anti-platelet therapy. Handb.Exp.Pharmacol. 210, 225-238 (2012). 2.Watanabe, N.,Adachi, H.,Takase, Y., et al. 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. Journal of Medicinal Chemistry 43(13), 2523-2529 (2000). 3.Coccheri, S. Antiplatelet drugs - do we need new options? Drugs 70(7), 887-908 (2010). 4.Fawcett, L.,Baxendale, R.,Stacey, P., et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proceedings of the National Academy of Sciences of the United States of America 97(7), 3702-3707 (2000). 5.Lin, W., and Buolamwini, J.K. Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. Journal of Medicinal Chemistry 50(60), 3906-3920 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 504.6 |
| 分子式 | C24H40N8O4 |
| CAS号 | 58-32-2 |
| 稳定性 | ≥ 2 years |
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