| 货号 | 18163-100mg |
| 描述 | Nifuroxazide is a broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin.1 Like other nitrofuran antibiotics, nifuroxazide is activated during metabolism by microbial nitroreductases.1 It has been shown to block quorum sensing in P. aeruginosa.2 Nifuroxazide also inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Quillardet, P.,Arrault, X.,Michel, V., et al. Organ-targeted mutagenicity of nitrofurantoin in Big Blue transgenic mice. Mutagenesis 21(5), 305-311 (2006). 2.Yang, L.,Rybtke, M.T.,Jakobsen, T.H., et al. Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors. Antimicrobial Agents and Chemotherapy 53(6), 2432-2443 (2009). 3.Nelson, E.A.,Walker, S.R.,Kepich, A., et al. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood 112(13, 5095-5102 (2008). 4.Yang, F.,Hu, M.,Lei, Q., et al. Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model. Cell Death Dis. 6(e1701), (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 275.2 |
| 分子式 | C12H9N3O5 |
| CAS号 | 965-52-6 |
| 稳定性 | ≥ 2 years |
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