7-Methylguanine
货号：
18161-50mg 基本售价：
350.0 元 规格：
50 mg
产品信息
概述| 货号 | 18161-50mg |
| 描述 | 7-Methylguanine is a metabolite of the natural purine base whose N9 position is available for chemical modifications.1 This genotoxic adduct can be generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods.2 It is also considered to be a carcinogenic biomarker for cigarette smoking that is detectable in urine.3 |
| 别名 | Epiguanine;2-Amino-7-methylhypoxanthine;N7-Methylguanine;NSC 193444;NSC 19647; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kozma, A.,Ibáñez, S.,Silaghi-Dumitrescu, R., et al. 7-Methylguanine: Protonation, formation of linkage isomers with trans-(NH3)2Pt(II), and base pairing properties. Dalton Trans. 41, 6094-6103 (2012).
2.Lee, S.,Bowman, B.R.,Ueno, Y., et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. Journal of the American Chemical Society 130(35), 11570-11571 (2008).
3.Lee, H.L.,Hsueh, Y.M.,Chung, C.J., et al. Correlation between the urine profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolites and N7-methylguanine in urothelial carcinoma patients. Cancer Epigemiol.Biomarkers Prev. 17(12), 3390-3395 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 165.2 |
| 分子式 | C6H7N5O |
| CAS号 | 578-76-7 |
| 稳定性 | ≥ 2 years |
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